GS II [Gram Scale]
Diagnostic Scale - Pilot Scale
Multi-Column RNA/DNA Synthesizer
column - 9 monomer reservoirs
LIST PRICE $175,000.USD
for the discerning, uncompromising customer who requires the highest
degree of precision in a synthesis platform necessary for assembling
biomolecules such as siRNA's.
GS II is a Custom DNA/RNA, siRNA synthesizer designed to operate with superior
efficiency at scales in the 140umole to 5mmole range. A variety column geometries and resin loadings can provide an increased
This system operates
with a single multi-speed gear pump, which affords high
reliability and producers higher quality oligomers over
conventional systems developed from a liquid chromatograph
nature of the gear pump provides for enhanced pre mixing of
reagents prior to delivery to the reactor. This is essential for
high quality oligonucleotide production.
The system can
synthesize DNA, RNA and hybrid molecules and along with the
standard nine monomers reservoirs. This system can
deliver up to 5 ancillary reagents and wash to the three column
reactors at a variable flow rates.
A QMaster GS Brochure
Information On QMaster Synthesizers
The system utilizes a fixed
through column reactor. The size show in this photograph is
capable of scales ranging from 250umole to 700umole. Additional
column reactors are available that will provide scale range from
140umole to 5mmole or greater depending on the support loading. Coupling
excess requirements are between 3 and 10 fold which is highly
competitive with industry standards. Cycle times are
approximately 12 minutes for standard DNA coupling and slightly
longer for RNA
higher loaded supports offered today provide extended scale
|System control is based on Genomic's
The system makes use of several
onboard sensors to control key synthesis operations. As the
synthesis environment of your oligonucleotide changes the system
adapts to provide the optimal coupling and deprotection
GS Reagent Consumption for RNA synthesis
||* Using Low Loading support
Using High Loading support (>70umole.gm)
High Loading support (>70umole.gm)
Key Features For GMP Operation
- All system operations are
logged for a complete process record.
- The system is equipped
with on-board diagnostics, which enable system validation
prior to synthesis operation.
- The system is equipped with a security
module that limits control of the synthesizer to authorized
users. The security module provides multiple level user access
including supervisor, operator and technician levels, in
compliance with FDA, CFR Part 11.
Keyboard and Mouse are Bluetooth enabled
for operation away from wetted areas.
Request Additional Information On
21 CFR Part 11
Practically speaking, Part 11 requires drug
makers, medical device manufacturers, biotech companies,
biologics developers, and other FDA-regulated industries, with
some specific exceptions, to implement controls, including
audits, system validations, audit trails, electronic
signatures, and documentation for software and systems
involved in processing electronic data that are (a) required
to be maintained by the FDA predicate rules or (b) used to
demonstrate compliance to a predicate rule.
The OligoMaster II is
designed to assist biotech companies, biologics
developers become part 11 compliant. The system
comprises several elements toward this goal.
The system can be run in
"Secure Mode". This mode addresses the needs of the
electronic signatures and limited control. Secure Mode
requires that all operators, administrators and service
persons log into the software before they can perform
operations on the system. The specific operations are limited
to the type of user that is logged in. For instance only an
Operator type user can perform a synthesis and only a Service
type of user can perform diagnostics. All users are
automatically logged out after a period of inactivity.
- The system comprises several
onboard diagnostic routines that went successfully run can
qualify the system parametrically.
- The system logs every
operation whether it be a synthesis, a diagnostic or
manual function. This is essential for audits.
- The system comprises several
sensors that control the operations of key steps in the
protocol. These sensors provide "closed loop"
confirmation of optimal operation while enhancing
- An optional "Validation
Documentation Pack" is available that includes IQ,
OQ, PQ, System
Requirement Specification , Software flow Diagram,
User Requirement Document, test protocol and a
Software Execution block diagram, which are critical
documents necessary for ISO compliance.
Validate Instrument Control System